Effect of Qianliening Granule on Experimental Hyperplasia of Prostate

Objective To study the effect of Qianliening on rats with benign prostatic hyperplasia. Methods 120 SD rats were divided randomly into blank group, model group, Baoliezhi control group and Qianliening granule groups with different doses. The models were established with hypodermic injection of testosterone propionate at 4 mg/kg after orchiectomy, at the same time, these rats were gastric perfused with different drugs respectively for 30 days. The body weight, prostate weight, prostate index, morphological changes, the level of T and E2 were measured. Results The body weight in model group was significantly lower than that in control group (P0.05), the prostate weight and index were obviously higher than that in control group (P0.01). The prostate weight and index were decreased significantly in Qianliening granule groups with meddle and high doses (P0.01), the level of testosterone was increased significantly and E2 was decreased obviously in Qianliening granule group with high doses. Conclusion Qianliening can decrease the prostate index and wet weight, and adjust the rate of T/E2, it shows an obvious dose-effect relationship on rats with benign prostatic hyperplasia.