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2004•Unpublished venueRequires access

Relationship between Insertion/deletion Polymorphism of Angiotensin Converting Enzyme Gene and Pregnancy-induced Hypertension Syndrome

Cheng Pei-lan

Open publisher page 2 citations

Abstract

Objective:To identify the relationship between the insertion/deletion(I/D)polymorphism of anˉgiotensin converting enzyme(ACE)gene and pregnancy-induced hypertension syndrome(PIH).Methods:ACE genotype was examined by polymerase chain reaction(PCR)in41patients with PIH and50normal conˉtrols.The activity of plasma ACE was measured simultaneously.Results:The frequency of DD genotype and the frequency of deletion allele in PIH were39%and61%respectively.They were higher than those in the normal controls(P0.05).The activity of ACE in the population with DD genotype was higher than the others.Conclusion:The DD genotype of ACE gene is probably an important hereditary factor of PIH.ACE activity can be controlled by the gene for the cause of higher activity of DD genotype.

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Objective:To identify the relationship between the insertion/deletion(I/D)polymorphism of anˉgiotensin converting enzyme(ACE)gene and pregnancy-induced hypertension syndrome(PIH).Methods:ACE genotype was examined by polymerase chain reaction(PCR)in41patients with PIH and50normal conˉtrols.The activity of plasma ACE was measured simultaneously.Results:The frequency of DD genotype and the frequency of deletion allele in PIH were39%and61%respectively.They were higher than those in the normal controls(P0.05).The activity of ACE in the population with DD genotype was higher than the others.Conclusion:The DD genotype of ACE gene is probably an important hereditary factor of PIH.ACE activity can be controlled by the gene for the cause of higher activity of DD genotype.

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Available abstract

Objective:To identify the relationship between the insertion/deletion(I/D)polymorphism of anˉgiotensin converting enzyme(ACE)gene and pregnancy-induced hypertension syndrome(PIH).Methods:ACE genotype was examined by polymerase chain reaction(PCR)in41patients with PIH and50normal conˉtrols.The activity of plasma ACE was measured simultaneously.Results:The frequency of DD genotype and the frequency of deletion allele in PIH were39%and61%respectively.They were higher than those in the normal controls(P0.05).The activity of ACE in the population with DD genotype was higher than the others.Conclusion:The DD genotype of ACE gene is probably an important hereditary factor of PIH.ACE activity can be controlled by the gene for the cause of higher activity of DD genotype.

Key concepts: Genotype, Allele, Angiotensin-converting enzyme, Polymerase chain reaction, Internal medicine, Gene, Endocrinology, Allele frequency

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Relationship between Insertion/deletion Polymorphism of Angiotensin Converting Enzyme Gene and Pregnancy-induced Hypertension Syndrome — Research Paper | ScholarLens