Clinical significance of HBV large protein detection in patients with chronic hepatitis B

Objective To investigate the clinical significance of hepatitis B virus large protein(HBV LP)in patients with chronic hepatitis B(CHB).Methods HBV LP level was analyzed by enzyme linked immunosorbent assay,serum marker of HBV were detected by chemo-luminescence method.,and HBV DNA was quantitatively detected by real-time quantitative polymerase chain reactioin.Results No significant difference of the detectable rate between HBV DNA and HBV LP was found in 317 cases of HBsAg positive patients(P0.01,Kappa=0.85).The positive rates of HBV DNA and HBV LP in 221 cases of HBeAg negative patients were 47.06% and 53.39% respectively,with statistical difference(P0.05).The absorbance(A value)of serum HBV LP was positively correlated with HBV DNA copies(r=0.982).Conclusion HBV LP could be a reliable serological marker,reflecting the replication of HBV,with important clinical value.