Low-grade fibromyxoid sarcoma:a clinicopathologic analysis of three cases

Objective To explore the clinicopathologic features of low-grade fibromyxoid sarcoma(LGFMS). Methods Three cases of LGFMS were analyzed by clinical data,pathomorphology and immunohistochemistry.Results Among the 3 patients studied,all of they were males.Patients ranged in age from 18 to 43 years(mean 31).The tumors were located in the thigh,the abdominal wall and the antebrachium.They measured from 3.0 to 5.0cm(greatest diameter).Histologically,the tumors were composed of a few bland spindle cell,with collagen deposition,pars fibrosa and irregularity myxoid district migration one another in matrix.Immunohistochemically,tumor cell were positive for vimentin,positive with Ki-67 were not so many as 2%,but negative for S-100,SMA,MSA,desmin,caldesmon,CD34 and bcl-2.In the following up 1 to 2 years,there was no relapse(case 1 lost follow-up).Conclusion LGFMS is a rare soft tissue neoplasm with a deceptively benign histologic appearance.The following tumors must be included in the differential diagnosis: Low-grade myxofibrosarcoma,myxoid liposarcoma,fibromatosis,myxoid neurofibroma,myxoid dermatofibrosarcoma protuberans,inflammatory myofibroblastic tumor and malignant fibrous histiocytomas.