The Analysis of MGMT and GST-π Protein Expression Detected by Flow Cytometry in Breast Carcinoma Tissues and Corresponding Para-Carcinoma Tissues

Objective Our purpose was to explore the clinical significance of MGMT and GST-π protein expression in breast carcinoma tissues and corresponding para-carcinoma tissues.Methods Flow cytometry was used to analyze the expression of MGMT and GST-π protein.Results The expression of MGMT and GST-π were higher in breast carcinoma tissues than that in corresponding para-carcinoma tissues(P 0.05).There were not notable differences of two drug resistance related protein expressions in different ages,different tumor sizes,different pathological types,different clinical stages,estrogen receptor or progestin receptor negative and positive patients (P 0.05).There was no notable difference of MGMT expression in lymph node metastasis negative and positive patients(P 0.05).The expression of GST-π was higher in lymph node metastasis positive patients than that in negative patients(P 0.05).The correlation analysis showed that there were no correlations between the expressions of MGMT and GST-π(P 0.05).Conclusion The preliminary research results suggest that MGMT protein expression had probably no correlation with prognosis of breast carcinoma patients,it could not become a prognosis target of breast carcinoma.The expression of GST-π had related with lymph node metastasis status,it can become a target in forecasting breast carcinoma prognosis.