Effects of Acute Cadmium Exposure on Glutathione Levels in Mice Livers and Kidneys

Objective] To study the effects of acute cadmium chloride exposure on GSH metabolism in mice livers and kidneys.[Methods] Mice were given a single ipinjection of cadmium chloride in different dose and 9 hours later, Cd and GSH、MDA concentration in the livers and kidney were determined.[Result] The cadmium contents in livers and kidneys of all exposured mice increased. in the higher dose Cd-treated group, Renal and hepatic MDA significantly increased and renal GSH were lower than that of the control group. At the same time, hepatic GSH was first raised and declined afterwards with dose of CdCl 2 exposure increased.[Conclusion] Cadmium can be accumulated and induced lipid peroxidation reaction in mice livers and kidneys after 9 hours CdCl 2 exposure; GSH metabolism of cadmium inducement in mice livers and kidneys may be different.