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2009•Chinese Journal of PharmaceuticalsRequires access

Simultaneous Determination of Pioglitazone and Metformin by Ion-pair HPLC

Zhong Ming-kang

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Abstract

An ion-pair HPLC method was established for the determination of metformin hydrochloride and pioglitazone hydrochloride. A C18 column was used,with the mobile phase of methanol-2 mmol/L SDS (56∶44) ,at the detection wavelength of 264 nm. The calibration curves of metformin hydrochloride and pioglitazone hydrochloride were linear in the concentration ranges of 400-600 μg/ml and 12-18 μg/ml. The recoveries were 99.2% and 99.1%,with RSDs of 0.31% and 0.62%.

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What this paper is about

An ion-pair HPLC method was established for the determination of metformin hydrochloride and pioglitazone hydrochloride. A C18 column was used,with the mobile phase of methanol-2 mmol/L SDS (56∶44) ,at the detection wavelength of 264 nm. The calibration curves of metformin hydrochloride and pioglitazone hydrochloride were linear in the concentration ranges of 400-600 μg/ml and 12-18 μg/ml. The recoveries were 99.2% and 99.1%,with RSDs of 0.31% and 0.62%.

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Available abstract

An ion-pair HPLC method was established for the determination of metformin hydrochloride and pioglitazone hydrochloride. A C18 column was used,with the mobile phase of methanol-2 mmol/L SDS (56∶44) ,at the detection wavelength of 264 nm. The calibration curves of metformin hydrochloride and pioglitazone hydrochloride were linear in the concentration ranges of 400-600 μg/ml and 12-18 μg/ml. The recoveries were 99.2% and 99.1%,with RSDs of 0.31% and 0.62%.

Key concepts: Pioglitazone, Chemistry, Metformin Hydrochloride, Chromatography, Calibration curve, High-performance liquid chromatography, Hydrochloride, Metformin

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