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2014•Chinese Journal of Clinical Obstetrics and GynecologyRequires access

Application of high-risk human papillomavirus viral load in women with abnormal cytology

Xiaoya Zhang

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Abstract

Objective To investigate the applicable value of HR-HPV(High-risk Human Papillomavirus, HR-HPV)testing on cervical lesion screening.Methods 872patients interpreted as abnormal cervical cytology took HR-HPV testing and all patients underwent colposcopy and biopsy.All patients were divided into five groups as NILM,CIN1,CIN2,CIN3and ICC.Association between HR-HPV load and CIN were evaluated by Spearman rank correlation.Results The positive rate of HR-HPV in NILM,CIN1,CIN2,CIN3and ICC was 25.2%, 53.4%,86.7%,96.4%and 100%,respectively(P0.01).There was significant difference between the viral load in NILM and CIN or ICC,while no significant difference was observed among the viral load in CIN1,CIN2, CIN3and ICC.Conclusion The HR-HPV viral load is significantly associated with the presence of CIN and ICC, while HPV viral load does not increase with severity of cervical neoplasia.

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Objective To investigate the applicable value of HR-HPV(High-risk Human Papillomavirus, HR-HPV)testing on cervical lesion screening.Methods 872patients interpreted as abnormal cervical cytology took HR-HPV testing and all patients underwent colposcopy and biopsy.All patients were divided into five groups as NILM,CIN1,CIN2,CIN3and ICC.Association between HR-HPV load and CIN were evaluated by Spearman rank correlation.Results The positive rate of HR-HPV in NILM,CIN1,CIN2,CIN3and ICC was 25.2%, 53.4%,86.7%,96.4%and 100%,respectively(P0.01).There was significant difference between the viral load in NILM and CIN or ICC,while no significant difference was observed among the viral load in CIN1,CIN2, CIN3and ICC.Conclusion The HR-HPV viral load is significantly associated with the presence of CIN and ICC, while HPV viral load does not increase with severity of cervical neoplasia.

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Available abstract

Objective To investigate the applicable value of HR-HPV(High-risk Human Papillomavirus, HR-HPV)testing on cervical lesion screening.Methods 872patients interpreted as abnormal cervical cytology took HR-HPV testing and all patients underwent colposcopy and biopsy.All patients were divided into five groups as NILM,CIN1,CIN2,CIN3and ICC.Association between HR-HPV load and CIN were evaluated by Spearman rank correlation.Results The positive rate of HR-HPV in NILM,CIN1,CIN2,CIN3and ICC was 25.2%, 53.4%,86.7%,96.4%and 100%,respectively(P0.01).There was significant difference between the viral load in NILM and CIN or ICC,while no significant difference was observed among the viral load in CIN1,CIN2, CIN3and ICC.Conclusion The HR-HPV viral load is significantly associated with the presence of CIN and ICC, while HPV viral load does not increase with severity of cervical neoplasia.

Key concepts: Medicine, Viral load, Colposcopy, Human papillomavirus, Cytology, Biopsy, Cervical intraepithelial neoplasia, HPV infection

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