Clinical analysis of concurrent chemotherapy and radiotherapy for advanced cervical cancer

Objective: To observe the clinical effect,adverse reaction,side effect,and long-term complication of concurrent chemotherapy and radiotherapy for cervical cancer.Methods: Divided 87 cervical cancer cases at Ⅲb stage into concurrent chemotherapy and radiotherapy group(A group) and radiotherapy group(B group) by envelop method.A group was treated by DDP 40 mg/d intravenous drip for 6 cycles,repeated every week.At the same time,radical radiotherapy was administered by intracavity after-loading therapy with one-daily external irradiation doses of 45Gy/25f/5w and brachytherapy to deliver a total dose 42Gy /6f to point A(The center of whole pelvic field was blocked after 17f).B group was treated by only radiotherapy.Results: The difference of short-term efficacy between two groups was significant(P0.05).5-year survival rates were 58% and 32% respectively with significant difference(P0.05).There was no significant difference in adverse effect and long-term complication(P0.05).Conclusion: Concurrent chemotherapy and radiotherapy for cervical cancer can strengthen therapeutic efficacy,elevate survival rate,and reduce adverse effect.