The influencing factors of liver fibrosis detection by Fibrotouch in patients with chronic hepatitis B

Objective To investigate the influcing factors of liver fibrosis detection by Fibrotouch in patients with chronic hepatitis B. Methods One hundred and eightycases of patients with chronic hepatitis B were enrolled into 2 groups, the non-cirrhotic group and the cirrhosis group. The differences of the LSM and the serological markers before and after treatment were compared in each group. Results The LSM values of the non-cirrhotic group before and after treatment were 13.25 ± 1.16 and 7.32 ± 0.65, respectively(P 0.05). The LSM values of thecirrhosis group before and after treatment were 23.76 ± 7.42 and 19.15 ± 6.82, respectively(P 0.05). And the LSM value in the non-cirrhotic group was lower than that in the cirrhosis group(P 0.05). Positive correlations were shown between the LSM values and ALT, AST, TBILand GGT in both the noncirrhotic group and the cirrhotic group(P 0.05). LSM values was negatively correlated with ALB(P 0.05), but was not correlated with ALP(P 0.05). LSM value was not correlated with PLT in the non- cirrhotic group(P 0.05), but LSM value was negatively correlated with PLT in thecirrhosis group(P 0.05). Conclusion Fibrotouch is an effective diagnosis method for liver stiffness detection in patients with chronic hepatitis B, but liver function, PLT and other factors should be taken into consideration on liver stiffness evaluations.