The New Development of Research on Synthesis of Cofibic Acid

Cofibic acid was a kind of important intermediate of synthesizing clofibrate and biclofibrate. Choosing a kind of high efficient catalyst and phase transfer catalyst for synthesis of cofibic acid with chlorophenol acid,acetone and sodium hydroxide as raw materials was an important step. The literature on the synthesis of cofibic acid in China was referenced,the influence of solid catalyst,liquid catalyst and phase transfer catalyst,temperature of dropping chloroform, reaction temperature and the reuse of acetone were introduced,and the details for synthesis of cofibic acid were pointed out.