Protective Effect of Tanshinone IIA on Myocardial Hypertrophy Signal Transduction System Protein Kinase B in Rats

Objective:To explore the effects of tanshinone ⅡA on cell signal transduction system protein kinase B in rats with pressure overload myocardial hypertrophy. Methods: To copy the model of rats myocardial hypertrophy through adopting partial coarctation in the thoracic aorta. 48 rats were randomly divided into sham group(group S),model group(group M), valsartan treatment group (group X),low-dose tanshinone treatment group (group LD), medium-dose tanshinone treatment group (group MD), high-dose tanshinone treatment group (groupHD),and detected respectively left ventricular mass index(LVMI), left ventricular posterior wall and septal thickness(LVPW,IVS)by highfrequenty ultrasonography, myocardial cells diameter by HE staining,content of p-Akt, p-Gsk3β in myocardial by western blot. Results: Compared with the sham group, left ventricular mass index, left ventricular posterior wall and septal thickness were increased(P0.05), and myocardial cells diameter were higher,and p-Akt ,p-Gsk3β were increased, in model group and all treatment group. compared with model group, left ventricular mass index, left ventricular posterior wall and septal thickness were decreased(P0.05), and myocardial cells diameter were smaller, and p-Akt, p-Gsk3β were decreased in all treatment group.But there were no significant difference among the low, medium, high-dose tanshinone treatment group ,and there were no significant difference among the valsartan treatment group and all dose tanshinone treatment group. Conclusion: Tanshinone ⅡA can act on the protein kinase B (Akt) signaling pathway ,to prevent myocardial hypertrophy.