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Effects of IFN-α1b on morphology and the expression of connective tissue growth factor in hepatic stellate cells

Hongxu Xu

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Abstract

AIM: To observe the effect of (IFN-α1b) on morphology and the expression of connective tissue growth factor (CTGF) in hepatic stellate cells (HSC). METHODS: HSC were cultured in vitro, and were treated with (IFN-α1b) and TGF-β_1. The changes of HSC on morphology were observed, and the expression of CTGF in HSC was assessed using reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: Phenomenon of apoptosis were observed in HSC treated with IFN-α1b. The expression of CTGF in HSC was decreased after treatment with (IFN-α1b) in control and TGF-β1-triggered groups. CONCLUSION: (IFN-α1b) is able to induce the apoptosis and suppress the expression of CTGF in HSC.

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AIM: To observe the effect of (IFN-α1b) on morphology and the expression of connective tissue growth factor (CTGF) in hepatic stellate cells (HSC). METHODS: HSC were cultured in vitro, and were treated with (IFN-α1b) and TGF-β_1. The changes of HSC on morphology were observed, and the expression of CTGF in HSC was assessed using reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: Phenomenon of apoptosis were observed in HSC treated with IFN-α1b. The expression of CTGF in HSC was decreased after treatment with (IFN-α1b) in control and TGF-β1-triggered groups. CONCLUSION: (IFN-α1b) is able to induce the apoptosis and suppress the expression of CTGF in HSC.

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Available abstract

AIM: To observe the effect of (IFN-α1b) on morphology and the expression of connective tissue growth factor (CTGF) in hepatic stellate cells (HSC). METHODS: HSC were cultured in vitro, and were treated with (IFN-α1b) and TGF-β_1. The changes of HSC on morphology were observed, and the expression of CTGF in HSC was assessed using reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: Phenomenon of apoptosis were observed in HSC treated with IFN-α1b. The expression of CTGF in HSC was decreased after treatment with (IFN-α1b) in control and TGF-β1-triggered groups. CONCLUSION: (IFN-α1b) is able to induce the apoptosis and suppress the expression of CTGF in HSC.

Key concepts: CTGF, Hepatic stellate cell, Connective tissue, Growth factor, Apoptosis, Morphology (biology), Transforming growth factor, Cell biology

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Effects of IFN-α1b on morphology and the expression of connective tissue growth factor in hepatic stellate cells — Research Paper | ScholarLens