Clinical Effect and Safety of Emergency Strengthened Atovastatin Calcium on Cerebral Infarction

Objective To observe the clinical effect and safety of emergency strengthened atovastatin calcium on cerebral infarction. Methods A total of 105 patients with cerebral infarction were selected in Department of Emergence,the Frist People's Hospital of Hefei from January 2013 to June 2015,and they were divided into conventional group( n = 56) and intensive group( n = 49) according to treatment programs. Patients of conventional group were treated with small- dose atovastatin( 20 mg per night),while patients of intensive group were treated with large- dose atovastatin( 40 mg per night). NIHSS and BI scores,blood lipid levels and liver function and muscle enzyme levels were compared between the two groups before and after treatment. Results Before treatment,no statistically significant differences of NIHSS or BI score was found between the two groups( P 0. 05); after treatment, NIHSS score of intensive group was statistically significantly higher than that of conventional group( P 0. 05),and BI score of intensive group was statistically significant lower than that of conventional group( P 0. 05). Before treatment,no statistically significant differences of serum level of TC,TG,HDL-C or LDL-C was found between the two groups( P 0. 05); after treatment, serum levels of TC and LDL-C of intensive group were statistically significantly lower than those of conventional group( P 0. 05),and no statistically significant differences of serum levels of TG and HDL-C was found between the two groups( P 0. 05). Before treatment and after treatment, no statistically significant differences of serum level of ALT, AST and CK was found between the two groups( P 0. 05). Conclusion Emergencystrengthened atovastatin calcium could significantly decrease the serum levels TC and LDL-C of the cerebral infarction patients,improve neurological function and daily living ability,and has no significant effect on liver function and CK.