2008•Zhonghua zhongyiyao xuekanRequires access

The Effect of Acantbepanax Senticosus Spaponin On The Expression of VEGF mRNA

Lin Dai-hua

Abstract

Objective:To investigate the effect of Acanthopanax senticosus spaponin (ASS) on the mRNA expression of vascular endothelial growth factor (VEGF) in human Hep G2, in order to study the mechanism of ASS on anti-angiogenesis. Methods: Hep G2 were incubated with ASS, the expression of VEGF mRNA was detected by RT-PCR assay. Results: ASS(250,500μg/mL) decreased the expression of VEGF mRNA (P0.01). Conclusion: ASS might inhibit angiogenesis by decreasing VEGF mRNA.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Messenger RNA, Angiogenesis, VEGF receptors, Vascular endothelial growth factor, Chemistry, Molecular biology, Real-time polymerase chain reaction, Andrology