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2013•Xiandai yufang yixueRequires access

Effect of Sanqingjiangtang decoction on activity of alpha-glycosidase

LV Li-xu

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Abstract

OBJECTIVE To evaluate inhibitory of Sanqingjiangtang decoction on activity of alpha-glucosidase.METHODS By establishing inhibitory model of alpha-glucosidase in vitro,Sanqingjiangtang decoction was screened,activity was assayed by the PNPG substrate and acarbose as control.RESULTS It was found that petroleum ether,ethylacetate and n-butanol extracts had higher inhibitory effect on yeast α-glucosidase than acarbose,and only n-butanol extract had higher inhibitory effect on activity of rat intestinal α-glucosidase than acarbose.CONCLUSION All the extracts from Sanqingjiangtang decoction has inhibitory effect on activity of α-glucosidase,n-butanol extract has inhibitory effect on activity of rat intestinal α-glucosidase.

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OBJECTIVE To evaluate inhibitory of Sanqingjiangtang decoction on activity of alpha-glucosidase.METHODS By establishing inhibitory model of alpha-glucosidase in vitro,Sanqingjiangtang decoction was screened,activity was assayed by the PNPG substrate and acarbose as control.RESULTS It was found that petroleum ether,ethylacetate and n-butanol extracts had higher inhibitory effect on yeast α-glucosidase than acarbose,and only n-butanol extract had higher inhibitory effect on activity of rat intestinal α-glucosidase than acarbose.CONCLUSION All the extracts from Sanqingjiangtang decoction has inhibitory effect on activity of α-glucosidase,n-butanol extract has inhibitory effect on activity of rat intestinal α-glucosidase.

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Available abstract

OBJECTIVE To evaluate inhibitory of Sanqingjiangtang decoction on activity of alpha-glucosidase.METHODS By establishing inhibitory model of alpha-glucosidase in vitro,Sanqingjiangtang decoction was screened,activity was assayed by the PNPG substrate and acarbose as control.RESULTS It was found that petroleum ether,ethylacetate and n-butanol extracts had higher inhibitory effect on yeast α-glucosidase than acarbose,and only n-butanol extract had higher inhibitory effect on activity of rat intestinal α-glucosidase than acarbose.CONCLUSION All the extracts from Sanqingjiangtang decoction has inhibitory effect on activity of α-glucosidase,n-butanol extract has inhibitory effect on activity of rat intestinal α-glucosidase.

Key concepts: Acarbose, Decoction, Alpha-glucosidase, Inhibitory postsynaptic potential, Chemistry, Petroleum ether, Traditional medicine, Yeast

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