ScholarLens Back to search
2013•China Medical DevicesRequires access

Relationship between CT Performance of Middle Ear Cholesteatoma and Expression of MMP-2 & MMP-9

MA Xiu-feng

Open publisher page 0 citations

Abstract

Objective To study the relationship between CT performance of middle ear cholesteatoma and expression of matrix metalloproteinase-2(MMP-2) and matrix metalloproteinase-9(MMP-9).Methods Tested the expression of MMP-2 and MMP-9 by immunohistochemical method in 50 cases of middle ear cholesteatoma,and analyzed its correlation with CT performance.Results Different extent of damage of auditory ossicle was displayed by cholesteatoma tympanitis CT.There is significant difference in the expression of MMP-2 and MMP-9(P0.001).Conclusion MMP-2,MMP-9 expression in cholesteatoma is positively related to the degree of ossicular destruction,and can be treated as poor prognostic markers of cholesteatoma tympanitis.

About this research paper

What this paper is about

Objective To study the relationship between CT performance of middle ear cholesteatoma and expression of matrix metalloproteinase-2(MMP-2) and matrix metalloproteinase-9(MMP-9).Methods Tested the expression of MMP-2 and MMP-9 by immunohistochemical method in 50 cases of middle ear cholesteatoma,and analyzed its correlation with CT performance.Results Different extent of damage of auditory ossicle was displayed by cholesteatoma tympanitis CT.There is significant difference in the expression of MMP-2 and MMP-9(P0.001).Conclusion MMP-2,MMP-9 expression in cholesteatoma is positively related to the degree of ossicular destruction,and can be treated as poor prognostic markers of cholesteatoma tympanitis.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the relationship between CT performance of middle ear cholesteatoma and expression of matrix metalloproteinase-2(MMP-2) and matrix metalloproteinase-9(MMP-9).Methods Tested the expression of MMP-2 and MMP-9 by immunohistochemical method in 50 cases of middle ear cholesteatoma,and analyzed its correlation with CT performance.Results Different extent of damage of auditory ossicle was displayed by cholesteatoma tympanitis CT.There is significant difference in the expression of MMP-2 and MMP-9(P0.001).Conclusion MMP-2,MMP-9 expression in cholesteatoma is positively related to the degree of ossicular destruction,and can be treated as poor prognostic markers of cholesteatoma tympanitis.

Key concepts: Cholesteatoma, Matrix metalloproteinase, Middle ear, Immunohistochemistry, Medicine, Ossicle, Matrix (chemical analysis), Pathology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Relationship between CT Performance of Middle Ear Cholesteatoma and Expression of MMP-2 & MMP-9 — Research Paper | ScholarLens