Effect of controlled low central venous pressure on visceral perfusion in elderly patients undergoing liver resection

Objective To observe the effect of controlled low central venous pressure on visceral perfusion in elderly patients undergoing liver resection. Methods Forty elderly patients underwent elective liver resection for primary liver cancer were randomly divided into the LCVP group and the control group with 20 cases in each. Central venous pressure(CVP), mean arterial pressure(MAP), heart rate(HR), cardiac output(CO), arterial carbon dioxide partial pressure(PaCO2), arterial pH values(pHa), gastric carbon dioxide partial pressure(PgCO2) and gastric pH values(pHi) were observed at time point of before LCVP(T0), 30 min after LCVP(T1), 60 min after LCVP(T2) and after surgery(T3). Results Compared with T0, the LCVP, MAP and CVP of T1and T2were significantly reduced, HR and CO of T1and T2were significantly increased in LCVP group(q=12.65, 8.45, 4.28, 3.19, 10.71, 9.34, 3.81, 3.41, P0.05). Compared with the control group, CVP and MAP of T1and T2were significantly reduced, CO of T1and T2were significantly increased in LCVP group(t=8.81, 6.62, 2.21, 12.76, 4.16, 2.45, P0.05). The differences of PaCO2, PgCO2, pHa and pHi of LCVP group were not statistically significant between two groups at the same point(t=1.75, 0.82, 0.00, 0.00, 1.64, 0.10, 1.58, 1.58; 0.68, 0.33, 0.89, 1.24, 0.79, 0.88, 1.24, 1.58, P0.05). Conclusion Maintaining CVP from 2 cmH2O to 5 cmH2O and duration less than 2 hours in LCVP has no significant adverse impact on visceral perfusion in elderly patients undergoing liver resection.