Comparison the effect between omeprazole and famotidine prevention of stress ulcer bleeding

Objective:To study the effects of omeprazole vs famotidine treating stress ulcer.Methods: 98 patients with severe brain diseases were randomly divided into two groups,omeprazole group(n=48) and famotidine group(n=50),the incidence of upper digestive tract hemorrhage and mortality caused by stress uler were analysed.Results: The incidence of upper digestive tract hemorrhage and mortality was 6.3% in omeprazole group,and 24.0% in famotidine group,respectively.The statistical difference was significant between two groups(P0.05).Conclusion: Omeprazole can decrease the incidence of stress ulcer complicating with severe brain diseases and decrease the mortality caused by upper digestive tract hemorrhage.