Diagnosis and Treatment for 30 Cases with Primary Biliary Cirrhosis

Objective To explore the diagnosis and treatment method for primary biliary cirrhosis(PBC).Methods To detect serum antimitochondrial antibody(AMA) and its M2(AMA-M2),PBC was diagnosed if AMA was positive,30 cases in all.According to symptoms and serum biochemistry index,they were divided into early,medium and late stages.For the patients in early stage(7 cases),ursodeoxycholic acid(UDCA) was used 250 mg tid;for the patients in medium and late stages(23 cases),UDCA of 250 mg tid was used,meanwhile,preduisone of 40 mg qd was used,it was reduced to 30 mg qd seven days later,5 mg was decreased every 7 days,until 10 mg qd was used for maintenance treatment.For the patients whose jaundice was not easy to cure,ademetionine of 1 000 mg for intravenous drip was used per day.Results AMA-M2 was positive in 29 cases(96.7%),jaundice was reduced 4 weeks after treatment in all the patients.For the patients in medium and late stages,jaundice was reduced 2 weeks after treatment.Conclusion AMA is a kind of specific serum marker for the diagnosis of PBC,UDCA is the first choice for the treatment of PBC.For the patients in medium and late stages,corticosteroid is necessary,ademetionine was useful for reducing jaundice.