2010•Letters in BiotechnologyRequires access

The Role of the Ubiquitin Like Protein ISG15 Coded by Interferon Stimulated Gene 15 in the Antiviral Innate Immune Response

HU Ri

Abstract

ISG15 protein coded by interferon stimulated gene 15(ISG15)is a crucial ragulater of the interferon signaling pathways.The expression of ISG15 could be strongly induced by typeⅠinterferons.ISG15 is the first ubiquitin-like modifier to be identified.ISGylation does not drive protein degradation,but rather parallels ubiquitin's activating effects and plays an important role in the innate antiviral response although the detail mechanism was still unknown yet.Recently,new functions of the ISG15 in innate antiviral response have been discovered.This review provided an overview of ISG15 and its fuctions in antiviral innate immune pesponse.

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Key concepts: ISG15, Innate immune system, Interferon, Ubiquitin, Biology, Interferon-stimulated gene, IRF3, Immune system