Influence and significance of NAC to the expression of ER and PR in patients with breast cancer

Objective: To study influence of NAC on the expression of ER and PR in patients with breast cancer and its correlation with clinical curative effects.Methods: From 2007 to 2009 the ER and PR expression before and after NAC of 63 patients with breast cancer were detected by immunohistochemistry.The neo-adjuvant chemotherapy regimen(TThpC regimen) was taxotere 70 mg·m-2 in day one,pirarubicin 60 mg in day one,cyclophosphamide 500 mg·m-2 in day one.Twenty-one days was one cycle.After 3-4 cycles,the patients were underwent surgical operation.The changes of ER and PR expression before and after NAC were compared and its correlation with NAC′s clinical curative effects was analyzed.Results: Among the 63 patients,6 cases(group A)showed a transformation of the expression of ER and PR from positive to negative,8 cases(group B)showed a transformation of the expression of ER and PR from negative to positive,37 cases(group C) kept the expression of ER and PR positive,12 cases(group D) kept the expression of ER and PR negative,with statistical alteration for ER and PR status due to NAC(P0.001),and non-statistical diversity for therapeutic effects between ER negative and positive patients(P=0.338) and between the four groups(P=0.491).Conclusion: NAC can chang the ER and PR expression status in patients with breast cancer,but there is no statistically related to clinical performance of NAC,and there is no relationsipe between the ER,PR expression status and NAC neither.