The sedation effect of dexmedetomidine in ophthalmic surgery under local anesthesia

Objective To evaluate the sedative effect of dexmedetomidine and propofol and the correlation of the conscious condition and BIS in ophthalmic surgery.Methods Forty patients,ASA Ⅰ～Ⅱ,who underwent elective ophthalmic surgery,were randomly divided into two groups based on the medications used for sedation:the dexmedetomidine group(Group D) and the propofol group(Group P).In Group D,the loading dose was 0.8 μg/kg,followed by 0.3 μg/(kg·h).In Group P,the loading dose was 0.5 mg/kg,followed by 2.5 mg/(kg·h).BIS,HR,MAP and Ramsay score were observed and recorded before and during the operation.Results The Ramsay scores were same in the two groups and BIS were lower in Group D compared with Group P(P 0.05).HR in Group D was also lower than Group P(P 0.05).Side effects of hopoxemia were observed only in Group P.Conclusion Compared with propofol,dexmedetomidine appears to have more advantages in patients with ophthalmic surgery under local anesthesia.In addition,the BIS is lower with dexmedetomidine sedation than propofol at the same sedative level.