The comparative study of two kinds of treatment mode of post-operation with portal vein tumor thrombus in primary hepatocellular carcinoma patients

Objective To evaluate treatment effects of different treatment patterns after operation in primary hepatocellular carcinoma( PHC) patients with portal vein tumor thrombus( PVTT),to explore the better mode of treatment after operation in PHC patients with PVTT.Methods 36 PHC patients with PVTT which could be excised were randomly divided into group A and group B.Group A patients in normal liver function month after post-operation was treated by transcatheter arterial chemoembolization( TACE),group B patients in normal liver function month after post-operation was treated by percutaneous trans-hepatic portal vein chemotherapy( PVC),and patients in normal liver function two months after post-operation was treated by TACE.Therapeutic effect and survival rate were compared between 2 groups.Results The median survival time was 13 months in A group of patients; the median survival time was 17 months in B patients.A group of patients for 1-year,2-year,3-year survival rates were 50%,22.2%,11.1%; B group of patients for 1-year,2-year,3 year survival rates were 77.8%,44.4%,33.3%,two group survival rate had significant difference( P 0.05).Conclusions PHC patients with PVTT after operation treated with dual interventional therapy( TACE + PVC) can get the more treatment effect than simple TACE treatment,and can prolong the survival time of patients.