2011•Journal of Ningxia Medical UniversityRequires access

BDNF Expression in Myocardial Ischemic Preconditioning and Its Significance

Yun Wang

Abstract

Objective To observe BDNF mRNA and protein expression in the myocardial ischemic preconditioning and its significance.Methods 54 male SD rats were randomly divided into control group(Con group),ischemia-reperfusion group(I/R group) and ischemic preconditioning group(IPC group).After establishment of I/R group and IPC group model,all rats were divided into 1h,3h,6h and 12h group after reperfusion.BDNF mRNA were detected by RT-PCR and the BDNF protein were detected by Western-blo.Results Compared with the Con group,the expression of BDNF mRNA and protein in I/R group and IPC group at each time in rats showed significant differences(P0.05);and compared I/R group with IPC group,the expression of BDNF mRNA and protein at same time in rats showed significant differences(P0.05).Conclusion Ischemic preconditioning can increase the expression of BDNF mRNA and protein.BDNF after the ischemic preconditioning has a protective effect on myocardial ischemia-reperfusion.

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Key concepts: Ischemic preconditioning, Messenger RNA, Protein expression, Ischemia, Internal medicine, Medicine, Myocardial ischemia, Endocrinology