Pathology and clinical features of the palate primary malignant melanoma with breast transfer and literature review

Purpose To investigate the clinicopathological characteristics and prognosis of the palate primary malignant melanoma with breast and other multiple organ metastasis.Methods A case of palatal primary amelanotic malignant melanoma with breast,liver and multiple organ metastasis was retrospectively studied and the related literatures were reviewed.Results The tumor cells of palate primary amelanotic malignant melanoma was varied which similar to sarcomatous lesions with a large number of neutrophil infiltration.The morphology in the metastatic foci was not entirely consistent with primary lesion,while there were pigments in the cytoplasmic of the tumour cell from metastatic foci.The malignant melanoma metastasized to the liver could not indistinguish from hepatocellular carcinoma.Immunohistochemically,the tumor cells in the primary lesion were positive for S-100 and negative for HMB-45,while the tumor cells in the metastatic foci were positive for both.Conclusion The palate primary malignant melanoma with breast and multiple organ metastasis was rare and easily misdiagnosed.The combination of HE,immunohistochemical results and history may necessary for correct diagnosis.