Study on the efficacy between entecavir and telbivudine in treating chronic hepatitis B patients

OBJECTIVE To study the efficacy and safety of entecavin(ETV) in the treatment of chronic hepatitis B patients.METHODS 63 cases of HBeAg positive chronic hepatitis B patients were selected randomly as treatment group,treated with ETV.Another 52 cases of HBeAg positive chronic hepatitis patients were selected as observation group,treated with telbivudine(TBD).Patients' liver function,HBV DNA level,hepatitis B serology marker were assessed at 0 week,12th week,24th week,36th week and 48th week.RESULTS The mean decline of patients' liver function,HBV DNA level and hepatitis B serology marker from baseline were significantly in both groups(P0.05).There was no significant difference between the two groups in HBeAg seroconversion and the decline grade of patients' liver functions.ETV was superior in decline grade of HBV DNA level(P0.05).CONCLUSION Both ETV and TBD are effective and safe for the treatment of chronic hepatitis B patients,but ETV is superior in inhibition of HBV replication.