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Biotransformation of curcumol by Penicillium urticae

Feng Qiu

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Abstract

Objective To study the biotransformation of curcumol by Penicillium urticae.Methods The method of one-step fermentation was used to study the biotransformation of curcumol.Two metabolites were isolated from the EtOAc extract of the broth by column chromatography on silica gel and preparative HPLC and identified by spectral data.Results Their structures were elucidated as 3α-hydroxycurcumol(2)and 11R-12-hydroxycurcumol(3).Conclusions Compound 2 is a new compound,and compound 3 is obtained through biotransformation of curcumol by Penicillium urticae for the first time.

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Objective To study the biotransformation of curcumol by Penicillium urticae.Methods The method of one-step fermentation was used to study the biotransformation of curcumol.Two metabolites were isolated from the EtOAc extract of the broth by column chromatography on silica gel and preparative HPLC and identified by spectral data.Results Their structures were elucidated as 3α-hydroxycurcumol(2)and 11R-12-hydroxycurcumol(3).Conclusions Compound 2 is a new compound,and compound 3 is obtained through biotransformation of curcumol by Penicillium urticae for the first time.

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Available abstract

Objective To study the biotransformation of curcumol by Penicillium urticae.Methods The method of one-step fermentation was used to study the biotransformation of curcumol.Two metabolites were isolated from the EtOAc extract of the broth by column chromatography on silica gel and preparative HPLC and identified by spectral data.Results Their structures were elucidated as 3α-hydroxycurcumol(2)and 11R-12-hydroxycurcumol(3).Conclusions Compound 2 is a new compound,and compound 3 is obtained through biotransformation of curcumol by Penicillium urticae for the first time.

Key concepts: Biotransformation, Silica gel, Chemistry, Fermentation, Chromatography, Column chromatography, Penicillium, Organic chemistry

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