2006•Hangtian yixue yu yixue gongchengRequires access
Changes of Calcitonin Gene Related Peptide in Efferent Vestibular System and Vestibular Nuclei in Rats with Motion Sickness
WU Sheng-x, Feng Li-nin
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Abstract
Objective To study the changes of calcitonin gene related peptide(CGRP) in the efferent vestibular system and vestibular nuclei in rats with motion sickness.Method Thirty rats were divided into 2 experimental groups and 1 control group,and rats in the 2 experimental groups were treated with rotatory stimuli for 30 min 1 time and 3 times respectively. CGRP in rat efferent vestibular system and vestibular nuclei were observed utilizing ABC immnunohistochemical technique.Result Number of CGRP immunoreactivity neurons in the efferent vestibular system and level of CGRP immunoreactivity in vestibular nuclei increased significantly in rats after rotatory stimuli, and the changes were greater in the goup with 3 times of stimuli than those in the group with 1 time of stimulus.Conclusion CGRP might play a role in the process of motion sickness in rat.