CHANGES OF COPEPTIN,cTnI AND Hs-CRP AND THEIR CLINICAL SIGNIFICANCE IN PATIENTS WITH ACUTE CORONARY SYNDROME

Objective To explore the clinical significance of C-terminal portion of provasopressin(Copeptin),cTnI and Hs-CRP in patients with acute coronary syndrome(ACS). Methods This study consisted of 194 patients who were hospitalized with chest pain.According to coronary angiography(CAG),they were classified into four groups as: CAG normal,unstable angina pectoris(UAP),non-ST elevation myocardial infarction(NSTEMI) and ST elevation myocardial infarction(STEMI).Plasma copeptin,cTnI and Hs-CRP were measured on admission. Results Plasma levels of copeptin,cTnI and Hs-CRP in patients of groups UAP,NSTEMI and STEMI were significantly higher than that in CAG normal group(H=42.57-141.35,P0.05).The levels of copeptin,cTnI and Hs-CRP in patients of groups NSTEMI and STEMI were higher than that in UAP group(H=9.72-107.45,P0.05).The patients with left main coronary stenosis had a higher level of copeptin,cTnI and Hs-CRP than those with a single-,double-or triple-branch coronary stenosis(H=7.26-35.72,P0.05). Conclusion Plasma level of copeptin,cTnI and Hs-CRP is elevated in ACS patients.Copeptin and cTnI,to some extent,may reflect the severity of coronary artery lesion,which is of a clinical value on risk stratification,therapeutic decision-making,and prognostic prediction for patients with ACS.