A Study on the Characteristics of Immunoglobulin in Malignant Plasma Cell Dyscrasia

Objective: To study the levels of serum proteins,immunoglobulins and M-proteins,and to examine the characteristics of M-proteins' location in the malignant plasma cell dyscrasia.Methods:(1) compare the different types of malignant plasma cell dyscrasia with non-malignant plasma cell dyscrasia,which has the same kind of high levels of immunoglobulins in three kinds of immunoglobulins(IgG,IgA,IgM);(2)A comparison was made in serum total proteins and globulins(G) among different types of the malignant plasma cell dyscrasia;(3) serum total proteins and globulins were examined and compared between the malignant and the non-malignant plasma cell dyscrasia,(4) A comparison was made as well in the location and concentration characteristics of electrophoretogram and serum levels of M-proteins among different types of malignant plasma cell dyscrasia.All the data were analyzed by T-test.Results: There was a remarkable difference in the serum levels of TP and G between the malignant and non-malignant plasma cell dyscrasia,with no marked difference in the levels of TP and G among different types of malignant plasma cell dyscrasia.There was a notable difference in the serum levels of three kinds of Ig(IgG,IgA and IgM)between different types of malignant and non-malignant plasma cell dyscrasia with corresponding Ig increase.The electrophorosis zones of different kinds of malignant plasma cell dyscrasia had their own distinct characteristics.Conclusion: The different kinds of malignant plasma cell dyscrasia have their higher levels of IgM,and the levels of the other two kinds of Ig stay in a lower position.The high levels of TP and G in the malignant plasma cell dyscrasia patients bring about the hyper globulinemia.