2010•ZhongchengyaoRequires access

Pharmacokinetics of Ginkgo biloba extract phospholipid complex in rats in vivo

Baochang Cai

Abstract

AIM: To prepare Ginkgo biloba extract phospholipid complex(GBP) with phospholipid and study the pharmacokinetics of quercetin,kaempferol and isorhamnetin in rats in vivo compared with Ginkgo biloba extract(GBE).METHODS: Twelve SD rats were divided randomly into two groups for the respective administration of a single dose of GBE and GBP.The concentrations of quercetin,kaempferol and isorhamnetin in 800 min in rats were determined by HPLC.The pharmacokinetic parameters were calculated by the software 3p97.RESULTS: The results showed that quercetin,kaempferol and isorhamnetin in rats were all fit to open single-compartment model.Compared with GBE,the bioavailability of quercetin,kaempferol and isorhamnetin in GBP were significantly increased.CONCLUSION: GBP can significantly improve the bioavailability of GBE in rats in vivo.

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Key concepts: Isorhamnetin, Kaempferol, Ginkgo biloba, Quercetin, Pharmacokinetics, Bioavailability, In vivo, Chemistry