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2006•Medical Journal of the Chinese People's Armed Police ForcesRequires access

Sequence polymorphisms of mitochondrial DNA D-loop region HVI in Tibetan population in China

Rongjian Su

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Abstract

Objective To study the genetic polymorphisms of the mitochondrial DNA(mtDNA) D-loop region in Lhasa Tibetan population in China.Methods Sequence polymorphisms of 30 unrelated Tibetan mtDNA D-loop hypervariable regionsⅠwere determined by PCR and direct sequencing.Results Fifty-one polymorphic sites and 28 haplotypes were identified in the sequences of 404 nucleotides for HV-Ⅰ,compared with the reference sequence.The genetic diversity was calculated to be 0.9862,and the genetic identity was 0.0466.Conclusions Sequence polymorphism of mtDNA D-loop region is very useful in forensic practice as a marker for individual identification.

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What this paper is about

Objective To study the genetic polymorphisms of the mitochondrial DNA(mtDNA) D-loop region in Lhasa Tibetan population in China.Methods Sequence polymorphisms of 30 unrelated Tibetan mtDNA D-loop hypervariable regionsⅠwere determined by PCR and direct sequencing.Results Fifty-one polymorphic sites and 28 haplotypes were identified in the sequences of 404 nucleotides for HV-Ⅰ,compared with the reference sequence.The genetic diversity was calculated to be 0.9862,and the genetic identity was 0.0466.Conclusions Sequence polymorphism of mtDNA D-loop region is very useful in forensic practice as a marker for individual identification.

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Available abstract

Objective To study the genetic polymorphisms of the mitochondrial DNA(mtDNA) D-loop region in Lhasa Tibetan population in China.Methods Sequence polymorphisms of 30 unrelated Tibetan mtDNA D-loop hypervariable regionsⅠwere determined by PCR and direct sequencing.Results Fifty-one polymorphic sites and 28 haplotypes were identified in the sequences of 404 nucleotides for HV-Ⅰ,compared with the reference sequence.The genetic diversity was calculated to be 0.9862,and the genetic identity was 0.0466.Conclusions Sequence polymorphism of mtDNA D-loop region is very useful in forensic practice as a marker for individual identification.

Key concepts: Hypervariable region, Mitochondrial DNA, D-loop, Genetics, Haplotype, Biology, Genetic diversity, mtDNA control region

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