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2009•Shenzhen Journal of Integrated Traditional Chinese and Western MedicineRequires access

MRI Study of the Secondary Degeneration of Neural Fibers after Cerebral Infarction

MA Jing-y

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Abstract

Objective To investigate the time course of anterograde and retrograde degeneration in neural fiber through diffusion tensor imaging (DTI). Methods Ten patients with a recent unilateral internal capsule infarct were evaluated with DTI at the first week (W1), the sixth (W6) and twelfth week (W12) respectively. Fractional anisotropy (FA) were measured at centrum semiovale, corona radiate, internal capsule, cerebral peduncle, and pons levels. Results Compared with the controls, the FA values of infarct side in the ipsilateral proximal fi ber and distal portion of pyramidal was signifi cantly decreased at W1, W6 and W12. Conclusion Subcortical cerebral infarction may result in anterograde degeration and retrograde degeneration in fiber tract through the primary lesion.

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What this paper is about

Objective To investigate the time course of anterograde and retrograde degeneration in neural fiber through diffusion tensor imaging (DTI). Methods Ten patients with a recent unilateral internal capsule infarct were evaluated with DTI at the first week (W1), the sixth (W6) and twelfth week (W12) respectively. Fractional anisotropy (FA) were measured at centrum semiovale, corona radiate, internal capsule, cerebral peduncle, and pons levels. Results Compared with the controls, the FA values of infarct side in the ipsilateral proximal fi ber and distal portion of pyramidal was signifi cantly decreased at W1, W6 and W12. Conclusion Subcortical cerebral infarction may result in anterograde degeration and retrograde degeneration in fiber tract through the primary lesion.

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Available abstract

Objective To investigate the time course of anterograde and retrograde degeneration in neural fiber through diffusion tensor imaging (DTI). Methods Ten patients with a recent unilateral internal capsule infarct were evaluated with DTI at the first week (W1), the sixth (W6) and twelfth week (W12) respectively. Fractional anisotropy (FA) were measured at centrum semiovale, corona radiate, internal capsule, cerebral peduncle, and pons levels. Results Compared with the controls, the FA values of infarct side in the ipsilateral proximal fi ber and distal portion of pyramidal was signifi cantly decreased at W1, W6 and W12. Conclusion Subcortical cerebral infarction may result in anterograde degeration and retrograde degeneration in fiber tract through the primary lesion.

Key concepts: Cerebral peduncle, Internal capsule, Medicine, Fractional anisotropy, Diffusion MRI, Pons, Pyramidal tracts, Lesion

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