The Content of Inflammatory Cytokines in the Patients with Acute Cerebral Hemorrhage and its Clinical Significance

Objective To investigate the content of inflammatory cytokines in the patients with acute cerebral hemorrhage(ACH) and its clinical significance.Methods Plasma interleukin-1β(IL-1β),tumer necrosis factor-alpha(TNF α) and intercellular adhesion molecule-1(sICAM-1) were measured in 40 healthy persons and 60 patients after the onset of ACH 24h,72h,10d and 15d.The size of brain edema on computed tomographic(CT) scan in ACH patients was determined at the corresponding time.Results(1) The plasma contents of IL-1β,TNF α,ICAM-1 in ACH patients were all significantly higher than those in healthy controls(P0.01).(2) There was no significant difference for plasma contents of IL-1β,TNF α,ICAM-1 in ACH patients after onset at 24h,72h and 10d(P0.05).However,plasma contents of IL-1β,TNFα,ICAM-1 in ACH patients after onset on 15d were apparently lower than those at 24h,72h and 10d(P0.01).(3) There was a positive correlation between the size of brain edema and the plasma contents of IL-1β,TNFα,ICAM-1 in ACH patients at the different period.Conclusions The plasma contents of the inflammatory cytokines can reflect the severity of the brain edema in ACH patients.To use the antagonist of inflammatory cytokines in early stage and to prevent and control the inflammation are very important for reducing brain edema and improving the prognosis.