2006•Acta Agriculturae ZhejiangensisRequires access
Study on the immune function of Zmu-1:DHP guinea pig
Diwen Liu
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Abstract
To investigate the immunology base of Zmu-1:DHP guinea pig sensitive to virus infection,the Ig and T lymphocytic proliferation rate were determined by ELISA and FCM means.The suitable immune dosage of OVA is 0.1 mg per guinea pig.After immunization with OVA,the level of characteristic IgG,IgG1,IgG2 in Zmu-1:DHP guinea pig serum is approximately the same as DHP guinea pig,but its T lymphocytic proliferation rate is prominently lower than that of DHP guinea pig.The content of IgE in both of guinea pig sera is very low.The variation of IgG1 content is larger between immunization groups with or without Al(OH)_3.The cytoimmune function of Zmu-1:DHP guinea pig is lower than that of DHP guinea pig and the body fluid immune function is as the same as DHP guinea pig.The lower T lymphocytic function is probably one of the causes of arousing more sensitive to some virus in Zmu-1:DHP guinea pig.Thus Zmu-1:DHP guinea pig may fit to be used as an infectious animal model,and to investigate the immunogenic mechanism.