Influence of sex on Propofol effect-site concentration during target con-trolled infusion

Objective To explore the influence of sex on Propofol effect-site concentration during the target controlled infusion(TCI). Methods From March to August 2014, in General Hospital of Air Force, 30 cases of thoracic or abdominal surgery patients would undergo general anesthesia were divided into two groups, according to gender, male group(group A) and female group(group B). Radial artery was cannulated for MAP monitoring and blood sampling, targetcontrolled infusion of Propofol was administered by Schnider TCI model with a single constant target plasma Propofol concentration of 4 μg/m L, and remifentanil was administered by Minto TCI model with a single constant target plasma remifentanil concentration 4 ng/m L. The bispectral index(BIS), target plasma Propofol concentration and effect-site concentration at each time point TCI 30 s(T0), 60 s(T1), loss of consciousness(T3), effect compartment concentration at4 μg/m L(T4) were also recorded. And blood sampling 2 m L through transradial artery measured Propofol actual blood drug concentration, continuous monitored MAP and heart rate. Results There was no BIS value and the plasma of Propofol among the four time points(P 0.05). The effect-site concentration of Propofol in group B was higher than that in group A at T4(P 0.05); but Propofol actual blood drug concentrations of two groups were compared, the difference was not statistically significant(P 0.05). Conclusion Compared with male, female need higher effect-site concentration of Propofol during the induction of anesthesia, and it is effect-site concentration of Propofol to determine the depth of anesthesia, not plasma concentration.