Evaluation on the analgesic and anti-inflammatory effect of flurbiprofen axetil Injection

【Objective】To estimate the analgesic and anti-inflammatory effects of Flurbiprofen Axetil Injection(Flu-A).【Methods】Acetic acid-induced mouse writhing model and formalin induced rat paw edema models were used to study the analgesic and anti-inflammatory effects of Flu-A.【Results】The results of the acetic acid-induced writhing behaviour in mice showed that Flu-A at 20,40 and 80 mg/kg could significantly reduce the writhing numbers as compared with control group,and indicated that Flu-A had analgesic activity.The results of the formalin test showed that Flu-A at 40 and 80 mg/kg could significantly reduce the flinch numbers and volume of right pawas compared with control group and showed peripheral analgesic and anti-inflammatory activity.The analgesic effect of Flu-A at 80 mg/kg were comparable with aspirin.【Conclusion】Flu-A have certain analgesic and anti-inflammatory activity.