NPM1 gene mutation and acute myeloid leukemia

NPM1(nucleophosmin,also named as B23,numatrin or N038) is a nucleophosmin that is localized mainly in the nucleolus,continuously shuttles between the nucleus and cytoplasm.Mutations in exon 12 cause cytoplasmic NPM1 localization,and consequently contribute to tumour development.NPM1 mutations correlate with normal karyotype acute myeloid leukemia,adult female,multilineage involvement,CD34 negativity,FLT3-ITD,special clinical feature and better prognosis.For the patients with NPM1-mutated/FLT3 ITD-negative,there is no different prognosis between allogeneic SCT and non-allogeneic SCT.Now how mutated NPM1 contributes to leukemogenesis still remains to be explored.