Relationship between pharmacokinetics and pharmadynamics of mycophenolic acid in liver transplant recipients

Objective To investigate the relationship between pharmacokinetics and pharmadynamics of mycophenolic acid(MPA)in liver transplant recipients.Methods Plasma MPA concentration were determined EMIT method before MMF dose and after dosing in 20 liver transplant patients received mycophenolate mofetil(MMF).The inhibitory capacity of serum MPA on proliferation of CEM cells was also monitored at 0,1 h and 2 h.Results The rate of proliferation of CEM cells before MMF administration was higher significantly than those at 1 h and 2 h after dosing(P0.05).The concentrations of MPA at 1 h and 2 h were conversely related with the rate of proliferation of CEM cells(P0.05).Conclusion After MMF dose,the inhibitory capacity of serum MPA on proliferation of CEM cells was enhanced significantly.This effect was related greatly to MPA concentrations.