Effects of different methods of taking medicine in antihypertensive patients with non-dipper hypertension

Objective:To investigate effects of different methods of taking medicine in antihypertensive patients with non-dipper hypertension.Method:60patients with stage 2or stage 3non-dipper hypertensive were randomly divided into two groups.Patients in group A(n=30)take felodipine sustained release tablet(Plendil)5mg qd and irbesartan 150mg qd at 7o'clock.Patients in group B(n=30)take Plendil 5mg qd(or irbesartan 150mg qd)at 7 o'clock and irbesartan 150mg qd(or Plendil 5mg qd)at 19o'clock.All patients were checked blood pressure with ambulatory blood pressure monitoring before and 4weeks after medication.Result:The decrease in value of mean systolic blood pressure,mean diastolic blood pressure and mean arterial pressure in group B were significantly larger than the values in group A 4weeks after medication(P0.05).The decrease in value of mean systolic blood pressure,mean diastolic blood pressure and mean arterial pressure at night in group B were significantly larger than the values in group A 4weeks after medication(P0.01).The smoothness index of mean systolic blood pressure and mean arterial pressure in group B was significantly higher than group A(P0.05).The smoothness index of mean systolic blood pressure,mean diastolic blood pressure and mean arterial pressure at night in group B was significantly higher than group A(P0.01).The circadian rhythm of blood pressure was changed from nondipper to dipper at 18case patients in group B after treatment,which was 4/30 in group A,(P0.01).Conclusion:Compared one time a day with two time a day,the method of taking medicine with combination long-effect antihypertensive drugs was better for the patients in stage 2and stage 3 non-dipper hypertension;blood pressure drop was more stable,and the circadian rhythm of blood pressure was better to resume to normal.