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2012•Journal of Emergency in Traditional Chinese MedicineRequires access

Investigation of Curcumin on the Expression of HIF-1α Protein and Proliferation in HaCaT Cells under Hypoxia Inducible

Zhe Hu

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Abstract

Objective: To investigate the in vitro mechanism of curcumin on HaCaT cells under hypoxia,and to understand the therapeutical mechanism of curcumin on psoriasis.Methods: By the immunohistochemistry method,the expressions of HIF-1α protein of HaCaT were treated with different concentrations of curcumin and the growths of HaCaT cells were investigated under hypoxia.Results: The proliferation of the cells and the expression of HIF-1α protein in HaCaT cells under hypoxia were declined significantly after the curcumin.Conclusion: Curcumin could inhibit the proliferation of the cells and the expression of HIF-1α protein in HaCaT cells under hypoxia.

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Objective: To investigate the in vitro mechanism of curcumin on HaCaT cells under hypoxia,and to understand the therapeutical mechanism of curcumin on psoriasis.Methods: By the immunohistochemistry method,the expressions of HIF-1α protein of HaCaT were treated with different concentrations of curcumin and the growths of HaCaT cells were investigated under hypoxia.Results: The proliferation of the cells and the expression of HIF-1α protein in HaCaT cells under hypoxia were declined significantly after the curcumin.Conclusion: Curcumin could inhibit the proliferation of the cells and the expression of HIF-1α protein in HaCaT cells under hypoxia.

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Available abstract

Objective: To investigate the in vitro mechanism of curcumin on HaCaT cells under hypoxia,and to understand the therapeutical mechanism of curcumin on psoriasis.Methods: By the immunohistochemistry method,the expressions of HIF-1α protein of HaCaT were treated with different concentrations of curcumin and the growths of HaCaT cells were investigated under hypoxia.Results: The proliferation of the cells and the expression of HIF-1α protein in HaCaT cells under hypoxia were declined significantly after the curcumin.Conclusion: Curcumin could inhibit the proliferation of the cells and the expression of HIF-1α protein in HaCaT cells under hypoxia.

Key concepts: HaCaT, Curcumin, Hypoxia (environmental), In vitro, Medicine, Cell biology, Protein expression, Cancer research

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