Studies on Preparation and Quality Evaluation of Albendazole Loaded-Chitosan Microspheres

Objective:To study the preparation technique of ABZ-CS-MS the encapsulation efficiency the drug-loading rate the average diameter and shape were investigated.Methods:albendazole-loaded chitosan microspheres for embolization were achieved by emulsification cross-linking process with liquid paraffin as oil phase chitosan as water phase Span-80 as emulsifier and glutaraldehyde as cross linking agent.The particle size and distribution of microspheres were analyzed by optical microscope and the surface characterization of the microspheres was identified with scanning electronic microscope(SEM).The interaction of the drug and the polymer was analyzed by Application of infrared spectroscopy(FT-IR) X-ray power diffraction(XRD) and differential scanning calorimetry(DSC).Results:The novel microspheres with a global shape and narrow distribution were prepared.The average diameter was about(153±7)μm the drug-Loading rate was(20.92±0.15)% and the encapsulation efficiency of microspheres was(25.37±0.22)%.The drug release behavior at 0.1 mol/L HCL phosphate buffered saline(pH=3.5) and phosphate buffered saline(pH=7.4) and physiological saline are all conformed weibull distribution model the best effect of which is in PBS(pH= 3.5).Conclusion:The technique was feasible and microspheres with high drug-Loading rate and evident effect of sustained drug release were prepared.The solubility property of the albendazole solid dispersions was increased obviously.