The clinical observation of percutaneous vertebroplasty combined with salmon calcitonin for the treatment of osteoporotic vertebral compression fracture

Objective To observe percutaneous vertebroplasty(PVP) combined with salmon calcitonin for the treatment of patients with osteoporotic vertebral compression fracture(OVCF) through comparative research.Methods The OVCF patients treated with PVP from Feb 2008 to Jan 2011 were randomly divided into two groups.The patients in treatment group were treated with intramuscular injection of salmon calcitonin after the operation for 3 weeks and nasal spray of salmon calcitonin after that at least for 3 months.The patients in control group were treated with PVP only.The clinical efficacies of the two groups were assessed with the visual analogue pain score(VAS) and the capability of living score(Barthel Index) before the operation,and 1 week,1 month,3 months,and 6 months after the operation,respectively.Results Pain of patients in both two groups was relieved significantly.However,the pain relieve at 1-,3-,and 6-month after the operation and the improvement of life quality in the treatment group were more significant than those in the control group.This difference became more significant along with the follow up time.Conclusion PVP combined with salmon calcitonin can effectively relieve the pain of OVCF patients and improve their life quality.It is worthy of clinical promotion.