Comparison of the Tracheal and Intravenous Lidocaine on Preventing Cardiovascular Response in the Children with General Anesthesia and Tracheal Intubation

Objective:To compare the clinical effects of the tracheal and intravenous lidocaine on preventing cardiovascular response in the children with general anesthesia and tracheal intubation.Methods:Fourty-five children of 1 to 12 years old were randomly allocated into tracheal group (Group T),venous group (Group V) and contral group(Group P).Induction of anesthesia was commenced by intravenous administration of propofol 3 mg/kg,fentanyl 2μg/kg and vecuronium 1.5 mg/kg.Patients of group T were given lidocaine aerosol by trachea and patients of group V were given lidocaine 1.5 mg/kg i.v before intubation 1.5 min.Change in heart rate (HR),systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded before induction of anesthesia,immediately intubation and at 1,3 and 5 min after intubation in all children.Results:There was no significant differences between 3 groups at immediately intubation with the exception of ascending HR,SBP,MAP in Group P(P0.05).Compared with other groups,SBP in Group V even decreased (P0.05).SBP and MAP in Group V were obviously lower than those of other groups(P0.05).The blood press in Group T decreased remarkably at 1 min after intubution compared with the baseline (P0.05).There were no significant difference in 3 groups at 3 min and 5 min after intubution.Conclusion:Both tracheal lidocaine aerosol and intravenous lidocaine can effectively prevent the cardiovascular response caused by tracheal intubation.Intravenous lidocaine can apply more stable hemodynamic status during endotracheal intubation.