Effect of oral estradiol valerate on the high sensitivity C-reactive protein in climacteric SD rats

Objective To investigate the effects of estrogen on the high sensitivity C-reactive protein(hs-CRP),IL-6.Methods Seventy SPF female SD rats,fifteen-month-old,were randomly divided into two groups by digital table method: treatment group and control group.The treatment group was given estradiol valerate orally,once per day,the control group was orally fed with physiological saline intragastric administration,once per day,fourteen weeks.After the treatment,blood samples were taken from the rats to assess the level of hs-CRP,IL-6.Results Fourteen weeks after intragastric administration,in the treatment group,serum hs-CRP level was lower than that in the control group(P 0.05);while the IL-6 level was lower than that in control group(P 0.05).Conclusion Intragastric administration of estradiol valerate might decrease the hs-CRP,so estradiol may play a positive protective role in cardiovascular disease prevention.