2012•The Journal of Clinical AnesthesiologyRequires access
Effect of intrathecal agmatin on hyperalgesia and spinal dorsal NMDA receptor 1 expression in mice with bone cancer pain
Zhong Ji-yin
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Abstract
Objective To investigate the effect of intrathecal agmatin on hyperalgesia and spinal dorsal NMDA receptor 1 expression in mice with bone cancer pain. Methods Fifty-six adult female SD rats weighing 180-220 g were randomly divided into 4 groups with 14 each: sham operation group(group A); bone cancer group(group B); control group(group C); agmatin group(group D). Group C and D received intrathecal injection with 10 ul saline or 160 mg/kg agmatin. Mechanical paw withdrawal latencies(MWT) was measured by von Frey silk. The expression of NR1 was investigated 120 min after intrathecal agmatin treatment.Results MWT was significantly decreased in group B,C, D than group A 7 days after successful bone cancer pain model building(P0.05). MWT was higher in group D than group B and C(P0.05). The expression of NR1 was increased in group B,C,D than group A(P0.05). The expression of NR1 was lower in group D than group B and C(P0.05).Conclusion This study shows that agmatin may be involved in the mechanism of bone cancer pain through NMDA receptor.