Characters and Therapy of Triple-Negative Breast Cancer

Objective To explore the characters and therapy of the triple-negative breast cancer(TNBC).Methods The pertinent literatures with key wordstriple-negative breast cancer,diagnosis,andtherapywere retrieved and reviewed.Results TNBC was a subtype of breast cancer characterized by negative expressions of estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor-2(HER-2).The clinicopathologic feature and prognosis of TNBC were distinct from other breast cancer.The age of onset was younger,disease free survival and total survival rate were lower in the patients with TNBC.At present,the therapy guideline was lack of TNBC,which referred to the non-TNBC,including local surgery,systemic chemotherapy,and the target therapy was at the clinical trial stage.Conclusions TNBC is one of heterogeneity characteristics for the breast cancer,which has extra much difference.For improving the TNBC prognosis,we hope that more and more significant markers to TNBC in the future are found,which are useful to make individuation treatment.