Expression of urokinase-type plasminogen activator(uPA),its receptor(uPAR) and their mRNA in hepatic carcinoma and significance

Objective: To explore the expression of urokinase-type plasminogen activator,(uPA),its receptor(uPAR,)their mRNA in hepatic carcinoma,its effects and mechanism.Methods: The expression of uPA and uPAR with their mRNA in 71 specimens of human hepatic tissue,including C 12,HCC 34 and PTT 25 were detected with immunohistochemistry and RT-PCR.The expression of uPA and uPAR and its mRNA correlating with clinical and pathological significance were compared and analysed.Results: The uPA and uPAR protein with their mRNA in HCC were significantly higher than that in C and in PTT(all P0.01);there was significant difference between PTT and C(all P0.05).Compared by the expression of uPA and uPAR protein with their mRNA in HCC with capsule invaded,intrahepatic and extrahepatic metastasis,there were significant higher than those integral capsule,without intrahe-patic and without extrahepatic metastasis(P0.05 or P0.01,)these expression was not significant correlation with the magnitude of HCC(all P0.05),with lower of Edmondson grade,they were higher stepup,but were not statistically significant.Conclusion: The uPA and uPAR show strongly expression in HCC and they may play significant roles in the generation,development,invasion and metastasis of HCC.