Expressions and clinical significance of P63,Calponin and D2-40 in myoepithelial cells of salivary gland tumors

OBJECTIVE:To analyze the expressions of P63,Calponin and D2-40 in myoepithelial cells of salivary gland tumors and to investigate the value of D2-40 in identification of myoepithelial cells in salivary gland tumor. METHODS:Various types of salivary gland tumor specimens were collected during surgeries in affiliated Yijishan Hospital from January 2004 to January 2010.We used immunohistochemical technique(S-P) to examine the expressions of P63,Calponin and D2-40 in each salivary gland tumor organization.RESULTS:P63,Calponin,D2-40 were expressed in myoepithelial cells,and the expressions of P63,Calponin,D2-40 were 82.14%,76.79%and 66.07%,respectively.D2-40 was expressed in polymorphic adenomas,adenoid cystic carcinoma,epithelial-myoepithelial carcinoma and the expressions were 94.12%,61.90%and 66.67%,respectively.D2-40 was not expressed in malignant polymorphic adenomas.The expression of D2-40 in polymorphic adenomas,tissues adjacent to the salivary gland malignancy and the cancerous tissues showed decreasing expressions that were significant(P0.05).CONCLUSION:D2-40 could be one kind of ideal salivary gland tumor myoepithelial cell marker.Low expression of D2-40 is probably an indicator of malignant progresion of salivary gland tumor.